HIV Management Guide for Clinical Care and ARV Guidelines

HIV Management Guide for Clinical Care and ARV Guidelines

Immunological tests

Immunological tests used to monitor HIV infection and disease

Andrew McLean-Tooke1, Martyn French2 Department of Clinical Immunology, Sir Charles Gairdner Hospital, Perth, WA UWA Medical School and School of Biomedical Sciences, University of Western Australia, Perth, WA Last Reviewed: September 2019 Introduction In addition to clinical and virological staging of HIV infection, patients should be staged immunologically as this provides prognostic information for the …

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Routine monitoring of blood lymphocyte subpopulations in people with HIV infection

In patients with HIV infection not receiving antiretroviral therapy (ART), the blood CD4+ T cell count or proportion (CD4+ T cells as a percentage of total lymphocytes) should be monitored because they relate to the extent of HIV disease and guide the use of prophylactic antimicrobial therapy to prevent opportunistic infections. However, there is limited …

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Assessment of HIV-specific T cells

In addition to measuring the blood count or proportion of total CD4+ T cells or CD4+ T cell subpopulations, it is also possible to assess the proportion of blood T cells that specifically respond to HIV antigens. Whilst this type of test is not used in the routine clinical setting, it has utility in research settings for …

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References

Gale HB, Gitterman SR, Hoffman HJ et al. Is frequent CD4+ T-lymphocyte count monitoring necessary for persons with counts >=300 cells/μL and HIV-1 suppression? Clin Infect Dis. 2013; 56:1340-3. McBride JA, Striker R. Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health? PLoS Pathog. 2017; …

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