In summary, the COVID-19 pandemic has shaped the delivery of HIV care, requiring innovative approaches in the context of emerging infectious diseases such as Mpox. Nurses play a key role at the complex intersection of HIV, Mpox and COVID-19 by integrating infection prevention and control measures, providing psychosocial support and patient education. Using their expertise and collaboration with multidisciplinary teams, nurses can optimise treatment outcomes and mitigate the impact of infectious diseases on vulnerable populations.