HIV Management Guide for Clinical Care and ARV Guidelines

HIV Management Guide for Clinical Care and ARV Guidelines

Co-Morbidities

Impact of co-infections on cardiovascular disease risk

Co-infections with other viral or bacterial pathogens may increase CVD risk by enhancing HIV-associated immune activation and inflammation or through direct effects on the vascular endothelium. The best studied of these pathogens is cytomegalovirus (CMV), which can activate endothelial cells, promote inflammation and has been associated with serious non-AIDS events, including CVD [52]. As yet, …

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Coronary artery disease outcomes

As discussed above, people with HIV infection experience coronary artery disease at approximately 1.5 times the rates seen in the general population. While initially thought to occur not only at higher rates but also prematurely [55], recent analyses have shown that coronary artery disease occurs at similar ages in people with HIV infection and the …

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References

Samji H, Cescon A, Hogg RS, Modur SP, Althoff KN, Buchacz K, et al. Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada. PLoS One 2013; 8(12):e81355. Smith C, Sabin CA, Lundgren JD, Thiebaut R, Weber R, Law M, et al. Factors associated with specific causes of …

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