Adult Antiretroviral Guidelines

US DHHS Guidelines with Australian Commentary

Guidelines

Appendix A: Key to Acronyms

This section has information on Appendix A: Key to Acronyms. Please click on the below links or follow the table of contents to access the information you are looking for. Study and Trial Names Drug Name Abbreviations General Terms

Drug Name Abbreviations

AU Comment: Zidovudine The DHHS guidelines refer to Zidovudine using the acronym ‘ZDV’ however in Australian settings it referred to using the acronym ‘AZT’. Acronym/Abbreviation Definition 3TC lamivudine ABC abacavir ATV atazanavir ATV/c atazanavir/cobicistat ATV/r atazanavir/ritonavir BIC bictegravir CAB cabotegravir CAB-LA cabotegravir long-acting COBI or c cobicistat d4T stavudine ddI didanosine DLV delavirdine DOR doravirine …

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General Terms

Acronym/Abbreviation Definition 17-BMP beclomethasone 17-monopropionate ACA Affordable Care Act ADAP AIDS Drug Assistance Program Ag/Ab antigen/antibody Al aluminum ALT alanine aminotransferase AMP average manufacturer price ART antiretroviral therapy ARTAS Anti-Retroviral Treatment and Access to Services ARV antiretroviral ASP average sales price AST aspartate aminotransferase AUC area under the curve AUD alcohol use disorder AUDIT-C Alcohol …

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Study and Trial Names

Acronym/Abbreviation Name ACTG AIDS Clinical Trials Group ADVANCE Assessing Donor Variability And New Concepts in Eligibility ARDENT ACTG A5257 trial ARTEMIS Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study ATLAS Antiretroviral Therapy as Long-Acting Suppression D:A:D Data Collection on Adverse Events of Anti-HIV Drugs ECHO Evidence for Contraceptive Options in HIV ENCORE Evaluation …

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Drug-Drug Interactions

This section has information on Drug-Drug Interactions. Please click on the below links or follow the table of contents to access the information you are looking for. Overview NNRTI interactions INSTI interactions HIV-1 gp120-Directed Attachment Inhibitors Interactions between INSTI & NNRTI or PI PI Drug interactions NRTI interactions CCR5 Antagonist Drug Interactions Interactions between PIs …

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Overview

AU Comment: Additional PK data and resources ARVs requiring specific acidity (e.g. ATV and RPV) may also be affected by the physiological effects of oral supplementation – variable concentration-specific effects of supplementation on gastric pH and absorption of ARVs cannot be excluded as having interaction potential RTV is also an inducer of glucuronosyl transferase (UDP-GT). …

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PI Drug interactions

Table 24a. Drug Interactions Between Protease Inhibitors and Other Drugs This table provides information on the known or predicted interactions between protease inhibitors (PIs) and non-antiretroviral (ARV) drugs. When information is available, interactions for boosted atazanavir (ATV) (with either ritonavir [RTV] or cobicistat [COBI]) and unboosted ATV are listed separately. The term “all PIs” refers …

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NNRTI interactions

AU Comment: rilpivirine (RPV) Despite there being no direct effect on RPV plasma concentration, high doses of oral supplements may modify gastric pH, thereby affecting RPV absorption – subsequent potential impact on maintenance of viral suppression. AU Comment: Between-class ARV switching in the context of between-class ARV switches, clinicians may need to factor in enzyme …

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NRTI interactions

Table 24c. Drug Interactions Between Nucleoside Reverse Transcriptase Inhibitors and Other Drugs (Including Antiretroviral Agents) This table provides information on the known or predicted interactions between nucleoside reverse transcriptase inhibitors (NRTIs) and non-antiretroviral drugs. Recommendations for managing a particular drug interaction may differ depending on whether a new antiretroviral (ARV) drug is being initiated in …

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INSTI interactions

This table provides information on the known or predicted interactions between integrase strand transfer inhibitors (INSTIs) (bictegravir [BIC], dolutegravir [DTG], elvitegravir [EVG], or raltegravir [RAL]) and non-antiretroviral (ARV) drugs. EVG is always coadministered with cobicistat. Cabotegravir (CAB) intramuscular (IM) plus rilpivirine (RPV) IM are co-packaged into a single product and are coadministered as a complete …

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