RV Components or Regimens | Reasons for Not Recommending as Initial Therapy |
---|---|
Combination INSTI + NNRTI | |
CAB plus RPV (PO or IM) |
|
DTG plus RPV |
|
NRTIs | |
ABC/3TC/ZDV (Coformulated) As triple-NRTI combination regimen |
|
ABC/3TC/ZDV plus TDF As quadruple-NRTI combination regimen |
|
d4T plus 3TC |
|
ddI plus 3TC (or FTC) |
|
ddI plus TDF |
|
ZDV/3TC |
|
NNRTIs | |
DLV |
|
ETR |
|
NVP |
|
PIs | |
ATV (Unboosted) |
|
DRV (Unboosted) |
|
FPV (Unboosted) or FPV/r |
|
IDV (Unboosted) |
|
IDV/r |
|
LPV/r |
|
NFV |
|
RTV as sole PI |
|
SQV (Unboosted) |
|
SQV/r |
|
TPV/r |
|
Entry Inhibitors | |
FTR gp120 Attachment Inhibitor |
|
IBA CD4 Post-Attachment Inhibitor |
|
MVC CCR5 Antagonist |
|
T20 Fusion Inhibitor |
|
Key: 3TC = lamivudine; ABC = abacavir; ART = antiretroviral therapy; ARV = antiretroviral; ATV = atazanavir; CAB = cabotegravir; CD4 = CD4 T lymphocyte; COBI = cobicistat; d4T = stavudine; ddI = didanosine; DLV = delavirdine; DRV = darunavir; DTG = dolutegravir; ECG = electrocardiogram; EFV = efavirenz; ETR = etravirine; FPV = fosamprenavir; FPV/r = fosamprenavir/ritonavir; FTC = emtricitabine; FTR = fostemsavir; GI = gastrointestinal; IBA = ibalizumab; IDV = indinavir; IDV/r = indinavir/ritonavir; IM = intramuscular; IV = intravenous; LPV = lopinavir; LPV/r = lopinavir/ritonavir; MVC = maraviroc; NFV = nelfinavir; NNRTI = non-nucleoside reverse transcriptase inhibitor; NRTI = nucleoside reverse transcriptase inhibitor; NVP = nevirapine; PI = protease inhibitor; PO = oral; RPV = rilpivirine; RTV = ritonavir; SJS = Stevens Johnson Syndrome; SQV = saquinavir; SQV/r = saquinavir/ritonavir; T20 = enfuvirtide; TDF = tenofovir disoproxil fumarate; TEN = toxic epidermal necrolysis; TPV = tipranavir; TPV/r = tipranavir/ritonavir; ZDV = zidovudine |
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ARV Components or Regimens Not Recommended as Initial Therapy
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ARV Components or Regimens Not Recommended as Initial Therapy
DHHS Last Updated: September 2022
The ARV Guidelines with Australian commentary is administered by ASHM
The Australian Government Department of Health
While the Australian Department of Health provides financial support for the ARV Guidelines, the material contained in this resource should not be taken to represent the views of the Australian Department of Health.