HIV Management Guidelines

HIV Management Guidelines

HIV-infectious Disease & Cancer

Management > HIV-infectious Disease & Cancer > Dermatological Conditions > Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) > Clinical presentation

Clinical presentation

Patients with SJS/TEN may present with a prodrome of fever, stinging eyes, painful swallowing, followed by development of dusky macules which progress to erosions and bullae. Epidermal detachment is common, which may lead to massive fluid loss and electrolyte imbalance. Any mucosal surface may be affected including the eyes, aerodigestive tract and genitalia. SJS is characterised by <10% body surface area involvement, TEN by >30% and SJS/TEN overlap by 10-30% coverage. (152)

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