Management of Co-Exposures
Sexually transmissible infections (STIs) Individuals presenting for non-occupational PEP (NPEP) require appropriate targeted testing for chlamydia, gonorrhoea, and syphilis as per Australian STI Management Guidelines at www.sti.guidelines.org.au. If symptoms of STIs are present, further tests, empirical treatment and follow-up are required. Hepatitis B (HBV) All patients presenting for PEP should be assessed for HBV (see […]
Additional Clinical Considerations
Pregnancy and breastfeeding The risk of HIV acquisition is increased during pregnancy, and the viraemia that occurs during HIV seroconversion leads to an increased risk of intrauterine HIV transmission.73 Antiretrovirals recommended for PEP can be safely used by people who are pregnant and/or breastfeeding and are recommended as first-line therapy. Antiretrovirals taken during lactation can […]
Phone support for clinicians
Refer to the table below for relevant support on PEP prescribing in your jurisdiction Region Contact Information ACT Canberra Sexual Health Centre: 02 5124 2184Mon – Fri 8:30am – – 5pm Canberra Afterhours Locum Medical Service: 1300 422 567Mon-Fri 6pm – 8:30amWeekends and Public Holidays, 24 hours NSW NSW PEP hotline: 1800 737 669 (1800 PEP NOW)7 days, […]
Information for patients
Patient information about PEP is available from Get PEP Local AIDS councils and health departments can also provide further information. Links to AIDS councils are available via Health Equity Matters (HEM – formerly AFAO). Information on HIV and PEP in multiple languages is available from the Multicultural HIV and Hepatitis Service.
Appendices
Appendix A: Evidence for 3-drug versus 2-drug PEP regimens There is no direct or compelling indirect evidence to support the greater efficacy of 3-over 2-drug regimens; rather, it has been extrapolated from evidence that a higher number of drugs or combination of drug classes have historically achieved better treatment outcomes for HIV. In previous years, […]
References
Gianacas C, Down I, Ellard J, et al. Experiences of HIV: The Seroconversion Study Final Report 2007-2015. Monograph, The Kirby Institute, UNSW Australia, Sydney, Australia. (https://www.kirby.unsw.edu.au/sites/default/files/documents/Experiences-of-HIV-Seroconversion-Study-Final-Report.pdf). Palich R, Martin-Blondel G, Cuzin L, et al. Experiences of HIV postexposure prophylaxis (PEP) among highly exposed men who have sex with men (MSM). Sex Transm Infect 2017;93(7):493-498. DOI: […]